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Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian Oscillation

The circadian clock possesses robust systems to maintain the rhythm approximately 24 h, from cellular to organismal levels, whereas aging is known to be one of the risk factors linked to the alternation of circadian physiology and behavior. The amount of many metabolites in the cells/body is altered...

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Autors principals: Atsushige Ashimori, Yasukazu Nakahata, Toshiya Sato, Yuichiro Fukamizu, Takaaki Matsui, Hikari Yoshitane, Yoshitaka Fukada, Kazuyuki Shinohara, Yasumasa Bessho
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021-05-01
Col·lecció:Frontiers in Neuroscience
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fnins.2021.647589/full
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