METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy
Purpose To explore the N6-methyladenosine (m6A) modification mechanism of taurine upregulated gene 1 (TUG1) and whether methyltransferase 3 (METTL3) can promote peroxisome proliferators-activated receptor γ coactivator 1 alpha (PGC-1α) transcription and alleviate mitochondrial dysfunction.Methods In...
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| Автори: | , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Taylor & Francis Group
2025-12-01
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| Серія: | Renal Failure |
| Предмети: | |
| Онлайн доступ: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2521455 |
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