Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants

ABSTRACT The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in the nasal epithelium constitutes the cellular basis of viral pathogenesis and transmissibility. Yet a r...

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Principais autores:	Man Chun Chiu, Cun Li, Xiaojuan Liu, Wenjun Song, Zhixin Wan, Yifei Yu, Jingjing Huang, Ding Xiao, Hin Chu, Jian-Piao Cai, Kelvin Kai-Wang To, Kwok Yung Yuen, Jie Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2022-08-01
Series:	mBio
Assuntos:	nasal organoids airway organoids SARS-CoV-2 ciliary damage tight junction
Acceso en liña:	https://journals.asm.org/doi/10.1128/mbio.01944-22
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