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Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation

Alzheimer's disease (AD) is a highly prevalent multifactorial disease for which Diabetes Mellitus (DM) is a risk factor. Abnormal phosphorylation and aggregation of tau is a key hallmark of AD. In animal models, DM induces or exacerbates the phosphorylation of tau, suggesting that DM may influence t...

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Autori principali: Judith M. van der Harg, Leslie Eggels, Fabian N. Bangel, Silvie R. Ruigrok, Rob Zwart, Jeroen J.M. Hoozemans, Susanne E. la Fleur, Wiep Scheper
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017-07-01
Serie:Neurobiology of Disease
Soggetti:
Alzheimer's disease
Diabetes mellitus
Phosphorylated tau
Protein kinase A
Insulin deficiency
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996117300785
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