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NMR metabolomics-guided DNA methylation mortality predictorsResearch in context

Summary: Background: 1H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals. Methods: Leveraging multi-omics data in four Dutch population studies (N = 5238,...

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Principais autores: Daniele Bizzarri, Marcel J.T. Reinders, Lieke Kuiper, Marian Beekman, Joris Deelen, Joyce B.J. van Meurs, Jenny van Dongen, René Pool, Dorret I. Boomsma, Mohsen Ghanbari, Lude Franke, Pieternella E. Slagboom, Erik B. van den Akker, J.M. Geleijnse, E. Boersma, W.E. van Spil, M.M.J. van Greevenbroek, C.D.A. Stehouwer, C.J.H. van der Kallen, I.C.W. Arts, F. Rutters, J.W.J. Beulens, M. Muilwijk, P.J.M. Elders, L.M. 't Hart, M. Ghanbari, M.A. Ikram, M.G. Netea, M. Kloppenburg, Y.F.M. Ramos, N. Bomer, I. Meulenbelt, K. Stronks, M.B. Snijder, A.H. Zwinderman, B.T. Heijmans, L.H. Lumey, C. Wijmenga, J. Fu, A. Zhernakova, J. Deelen, S.P. Mooijaart, M. Beekman, P.E. Slagboom, G.L.J. Onderwater, A.M.J.M. van den Maagdenberg, G.M. Terwindt, C. Thesing, M. Bot, B.W.J.H. Penninx, S. Trompet, J.W. Jukema, N. Sattar, I.C.C. van der Horst, P. van der Harst, C. So-Osman, J.A. van Hilten, R.G.H.H. Nelissen, I.E. Höfer, F.W. Asselbergs, P. Scheltens, C.E. Teunissen, W.M. van der Flier, J. van Dongen, R. Pool, A.H.M. Willemsen, D.I. Boomsma, H.E.D. Suchiman, J.J.H. Barkey Wolf, D. Cats, H. Mei, M. Slofstra, M. Swertz, M.J.T. Reinders, E.B. van den Akker
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-09-01
coleção:EBioMedicine
Assuntos:
DNA methylation predictors
NMR metabolomics
Ageing biomarkers
Epigenetic clock
Metabolic risk score
Epidemiology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396424003153
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