Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes

Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav, using voltage-clamp techniques in Xenopus ooc...

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Autores principales:	Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Dan Okura, Takeyoshi Sata
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2012-01-01
Colección:	Journal of Pharmacological Sciences
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1347861319304657
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