Synthesis and biological evaluation of heteroarylnitrile derivatives for motile ciliogenesis

Motile cilia play a critical role in maintaining tissue homeostasis by driving fluid movement and clearing inhaled particles or pathogens. Dysfunction of these organelles underlies a range of ciliopathies, most notably affecting the respiratory system. Building on previous studies that identified mo...

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Prif Awduron:	Gwi Bin Lee, Gopalakrishnan Chandrasekaran, Da Bin Jeon, Chan-Young Park, Parvathi Varier Sundareswaran, Byeong Wook Choi, Pyeongkeun Kim, Jihyeon Yoon, Seok-Yong Choi, Jin Hee Ahn
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2026-03-01
Cyfres:	Results in Chemistry
Pynciau:	Motile cilia FOXJ1 Multiciliated cells(MCCs) Ciliogenesis Small-molecule therapeutics
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2211715626000512
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