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Assessing the Formation of Purine Lesions in Mitochondrial DNA of Cockayne Syndrome Cells

Mitochondrial (mt) DNA and nuclear (n) DNA have known structures and roles in cells; however, they are rarely compared under specific conditions such as oxidative or degenerative environments that can create damage to the DNA base moieties. Six purine lesions were ascertained in the mtDNA of wild ty...

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Principais autores: Chryssostomos Chatgilialoglu, Marios G. Krokidis, Annalisa Masi, Sebastian Barata-Vallejo, Carla Ferreri, Barbara Pascucci, Mariarosaria D’Errico
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-11-01
Serier:Biomolecules
Fag:
mitochondrial and nuclear DNA damage
5′,8–cyclopurines
8–oxo–dG
gamma radiolysis
hydroxyl radical
isotope dilution LC–MS/MS
Online adgang:https://www.mdpi.com/2218-273X/12/11/1630
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