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Dysregulated PI3K Signaling in B Cells of CVID Patients

The altered wiring of signaling pathways downstream of antigen receptors of T and B cells contributes to the dysregulation of the adaptive immune system, potentially causing immunodeficiency and autoimmunity. In humans, the investigation of such complex systems benefits from nature’s experiments in...

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Principais autores: Ina Harder, Matthias Münchhalfen, Geoffroy Andrieux, Melanie Boerries, Bodo Grimbacher, Hermann Eibel, Maria Elena Maccari, Stephan Ehl, Jürgen Wienands, Julia Jellusova, Klaus Warnatz, Baerbel Keller
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-01-01
Serier:Cells
Fag:
CVID
B cells
immune dysregulation
PI3K
mTOR
S6
Online adgang:https://www.mdpi.com/2073-4409/11/3/464
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