Collagen‐Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections

Background Cardiac fibrosis complicates SARS‐CoV‐2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of increased HSP47 (heat shock protein 47), a stress‐inducible chaperone protein that regulates biosynthesis and secretion of procollagen in hea...

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Principais autores:	Andrii Puzyrenko, Elizabeth R. Jacobs, Nathan Padilla, Adam Devine, Michael Aljadah, Benjamin N. Gantner, Amy Y. Pan, Shuping Lai, Qiang Dai, Jason C. Rubenstein, Paula E. North, Pippa M. Simpson, Rodney E. Willoughby, Caitlin C. O'Meara, Michael A. Flinn, John W. Lough, El‐Sayed H. Ibrahim, Ze Zheng, Yunguang Sun, Juan Felix, Bryan C. Hunt, Gracious Ross, Hallgeir Rui, Ivor J. Benjamin
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Wiley 2023-02-01
סדרה:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
נושאים:	cardiac fibrosis COVID‐19 endoplasmic reticulum heat shock proteins human autopsy stress
גישה מקוונת:	https://www.ahajournals.org/doi/10.1161/JAHA.122.027990
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!