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Severe Candida glabrata pancolitis and fatal Aspergillus fumigatus pulmonary infection in the setting of bone marrow aplasia after CD19-directed CAR T-cell therapy – a case report

Abstract Background Prolonged myelosuppression following CD19-directed CAR T-cell transfusion represents an important, yet underreported, adverse event. The resulting neutropenia and multifactorial immunosuppression can facilitate severe infectious complications. Case presentation We describe the cl...

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Main Authors: Kai Rejeski, Wolfgang G. Kunz, Martina Rudelius, Veit Bücklein, Viktoria Blumenberg, Christian Schmidt, Philipp Karschnia, Florian Schöberl, Konstantin Dimitriadis, Louisa von Baumgarten, Joachim Stemmler, Oliver Weigert, Martin Dreyling, Michael von Bergwelt-Baildon, Marion Subklewe
Format: Artigo
Language:Inglês
Published: BMC 2021-01-01
Series:BMC Infectious Diseases
Subjects:
CAR T-cell
Case report
Hematotoxicity
Candida glabrata
Invasive aspergillosis
Online Access:https://doi.org/10.1186/s12879-020-05755-4
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