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Imeglimin suppresses glucagon secretion and induces a loss of α cell identity

Summary: Dysregulated α cell function contributes to the development of diabetes. In this study, we find that treatment with imeglimin, an antidiabetic drug, prevents glucagon release and induces a loss of α cell identity through direct action on α cells. Mechanistically, imeglimin reduces Gsα expre...

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Hlavní autoři: Takahiro Tsuno, Jinghe Li, Kuniyuki Nishiyama, Yuka Imamura Kawasawa, Ryota Inoue, Esther Ong Yajima, Akira Nishiyama, Shigeharu G. Yabe, Tatsuya Kin, Hitoshi Okochi, Tomohiko Tamura, A.M. James Shapiro, Seiichi Oyadomari, Tadahiro Kitamura, Yasuo Terauchi, Jun Shirakawa
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2025-08-01
Edice:Cell Reports Medicine
Témata:
α cells
glucagon
human islets
imeglimin
C/EBP homologous protein
MafB
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2666379125003271
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