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Somatic NGS Analysis of DNA Damage Response (DDR) Genes <i>ATM</i>, <i>MRE11A</i>, <i>RAD50</i>, <i>NBN</i>, and <i>ATR</i> in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemo-Radiotherapy

Background: Neoadjuvant chemo-radiotherapy (nCRT) represents the standard of care for locally advanced rectal cancer (LARC); however, there exists no biomarker that can predict the cancer’s response to treatment as less than 20% of patients experience pathological complete response (pCR). Ionizing r...

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Hoofdauteurs: Andrea Montori, Aldo Germani, Mario Ferri, Annalisa Milano, Teresa Valentina Ranalli, Maria Piane, Emanuela Pilozzi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2022-12-01
Reeks:Biomedicines
Onderwerpen:
rectal cancer
ATM
RAD 50
MRN complex
NGS analysis
Online toegang:https://www.mdpi.com/2227-9059/10/12/3247
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