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Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape

Abstract Exosomes are key mediators of communication between tumor cells and the tumor microenvironment(TME); however, the mechanisms underlying exosome-mediated crosstalk between tumor cells and macrophages remain largely unclear. This study investigated the effect of exosomal RAB10 on macrophage p...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tang Guohui, Pang Bo, Yuting Liu, Shaopeng Xu, Li Ruonan, Zhu Chengle, Wu Qiong, Ran Ruorong, Haotian Cai, Wang Wenrui, Chen Changjie, Yang Qingling
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-01-01
Schriftenreihe:Cell Communication and Signaling
Schlagworte:
RAB10
Breast cancer
Exosomes
Macrophage polarization
scRNA-seq
Online-Zugang:https://doi.org/10.1186/s12964-026-02681-x
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