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Identification and validation of depression-associated genetic variants in the UK Biobank cohort with transcriptome and DNA methylation analyses in independent cohorts

Depression is one of the most common psychiatric conditions resulting from a complex interaction of genetic, epigenetic and environmental factors. The present study aimed to identify independent genetic variants in the protein-coding genes that associate with depression and to analyze their transcri...

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Principais autores: Muataz S. Lafta, Aleksandr V. Sokolov, Gull Rukh, Helgi B. Schiöth
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-01-01
Serier:Heliyon
Fag:
UK biobank
Depression
Independent genetic variants
Genetic risk score
Transcriptome
Methylation
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844025002452
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