Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice

Mitoxantrone (MTX) is a pharmaceutical drug used in the treatment of several cancers and refractory multiple sclerosis (MS). Despite its therapeutic value, adverse effects may be severe, namely the frequently reported cardiotoxicity, whose mechanisms need further research. This work aimed to assess...

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Autori principali:	Ana Reis-Mendes, José Luís Dores-Sousa, Ana Isabel Padrão, Margarida Duarte-Araújo, José Alberto Duarte, Vítor Seabra, Salomé Gonçalves-Monteiro, Fernando Remião, Félix Carvalho, Emília Sousa, Maria Lourdes Bastos, Vera Marisa Costa
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-05-01
Serie:	Pharmaceuticals
Soggetti:	mitoxantrone cardiotoxicity inflammation oxidative stress age cumulative dose
Accesso online:	https://www.mdpi.com/1424-8247/14/6/510
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