β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Abstract Irinotecan (CPT11)‐induced diarrhea affects 80–90% of cancer patients due to β‐glucuronidase (GUS) converting 7‐ethyl‐10‐hydroxycamptothecin glucuronide (SN38G) to 7‐ethyl‐10‐hydroxycamptothecin (SN38). It remains unclear whether SN38 impacts the homeostasis between gut microbiota and mucos...

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Autores principales:	Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2025-07-01
Colección:	Advanced Science
Materias:	epithelial regeneration irinotecan‐induced intestinal toxicity GUS‐expressing bacteria lactobacillus reuteri Xianglian pill
Acceso en línea:	https://doi.org/10.1002/advs.202411052
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