TGFβ level in healthy and children with Marfan syndrome—effective reduction under sartan therapy

IntroductionTransforming growth factor β (TGFβ) metabolism plays an important role in the pathogenesis of Marfan syndrome (MFS). Accordingly, drug therapy uses TGFβ receptor blockade to slow down the cardiovascular manifestations, above all aortic root dilatation. Angiotensin II type 1 receptor bloc...

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Bibliografiske detaljer

Principais autores:	Veronika C. Stark, Jakob Olfe, Daniel Diaz-Gil, Yskert von Kodolitsch, Rainer Kozlik-Feldmann, Johannes Reincke, Maria Stark, Peter Wiegand, Tanja Zeller, Thomas S. Mir
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2024-02-01
Serier:	Frontiers in Pediatrics
Fag:	Marfan TGFβ sartan connective tissue disorder genetic aortic disease aortic dilatation
Online adgang:	https://www.frontiersin.org/articles/10.3389/fped.2024.1276215/full
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