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An <i>Aedes aegypti</i>-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

Mosquitoes are known as important vectors of many arthropod-borne (arbo)viruses causing disease in humans. These include dengue (DENV) and Zika (ZIKV) viruses. The exogenous small interfering (si)RNA (exo-siRNA) pathway is believed to be the main antiviral defense in arthropods, including mosquitoes...

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Principais autores: Christina Scherer, Jack Knowles, Vattipally B. Sreenu, Anthony C. Fredericks, Janina Fuss, Kevin Maringer, Ana Fernandez-Sesma, Andres Merits, Margus Varjak, Alain Kohl, Esther Schnettler
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-06-01
Serier:Viruses
Fag:
RNAi
exo-siRNA pathway
Ago2
Dcr2
knockout cell line
arbovirus replication
Online adgang:https://www.mdpi.com/1999-4915/13/6/1066
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