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Identification of a physiologic vasculogenic fibroblast state to achieve tissue repair

Here, the authors report on the discovery of physiological vasculogenic fibroblasts capable of forming functional blood vessels. In vivo tissue reprogramming triggered by topical tissue nanotransfection (TNT) of a single anti-miR-200b oligonucleotide achieved therapeutic tissue vascularization.

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Principais autores: Durba Pal, Subhadip Ghatak, Kanhaiya Singh, Ahmed Safwat Abouhashem, Manishekhar Kumar, Mohamed S El Masry, Sujit K. Mohanty, Ravichand Palakurti, Yashika Rustagi, Saba Tabasum, Dolly K. Khona, Savita Khanna, Sedat Kacar, Rajneesh Srivastava, Pramod Bhasme, Sumit S. Verma, Edward Hernandez, Anu Sharma, Diamond Reese, Priyanka Verma, Nandini Ghosh, Mahadeo Gorain, Jun Wan, Sheng Liu, Yunlong Liu, Natalia Higuita Castro, Surya C. Gnyawali, William Lawrence, Jordan Moore, Daniel Gallego Perez, Sashwati Roy, Mervin C. Yoder, Chandan K. Sen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2023-02-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-023-36665-z
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