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A Mitochondrion-Targeting Protein (B2) Primes ROS/Nrf2-Mediated Stress Signals, Triggering Apoptosis and Necroptosis in Lung Cancer

The betanodavirus B2 protein targets mitochondria and triggers mitochondrion-mediated cell death signaling in lung cancer cells; however, its molecular mechanism remains unknown. In this study, we observed that B2 triggers hydrogen peroxide/Nrf2-involved stress signals in the dynamic regulation of n...

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Principais autores: Hsuan-Wen Chiu, Shao-Wen Hung, Ching-Feng Chiu, Jiann-Ruey Hong
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-01-01
Serier:Biomedicines
Fag:
anticancer peptide
lung cancer cell
apoptosis
necroptosis
mitochondrial targeting
NOD/SCID mice
Online adgang:https://www.mdpi.com/2227-9059/11/1/186
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