Cell-specific epigenome-wide DNA methylation in peripheral CD4(+) lymphocytes from patients with primary biliary cholangitis

Background/aims: Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease, triggered by a complex interplay between genetic, environmental and epigenetic factors. We investigated the methylation profile of peripheral CD4(+) lymphocytes from PBC patients compared to healthy...

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Detalhes bibliográficos

Principais autores:	Pinelopi Arvaniti, Kalliopi Zachou, Aggeliki Lyberopoulou, Eirini Sevdali, Stella Gabeta, Matthaios Speletas, Yves Renaudineau, George N. Dalekos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-12-01
coleção:	Journal of Translational Autoimmunity
Assuntos:	Primary biliary cholangitis Autoimmune hepatitis Hypermethylation DMPs X chromosome
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589909025000498
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