Bacillus Calmette-Guérin vaccination as defense against SARS-CoV-2 (BADAS): a randomized controlled trial to protect healthcare workers in the USA by enhanced trained immune responses

Abstract Background A large epidemic, such as that observed with SARS-CoV-2, seriously challenges available hospital capacity, and this would be augmented by infection of healthcare workers (HCW). Bacillus Calmette-Guérin (BCG) is a vaccine against tuberculosis, with protective non-specific effects...

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Principais autores:	Andrew R. DiNardo, Moshe Arditi, Ashish M. Kamat, Kent J. Koster, Santiago Carrero, Tomoki Nishiguchi, Maxim Lebedev, Aaron B. Benjamin, Pablo Avalos, Marisa Lozano, Madeleine G. Moule, Brittany McCune, Baysia Herron, Malik Ladki, Daanish Sheikh, Matthew Spears, Ivan A. Herrejon, Courtney Dodge, Sathish Kumar, Robert W. Hutchison, Theresa U. Ofili, Lynne A. Opperman, Jessica A. Bernard, Seth P. Lerner, George Udeani, Gabriel Neal, Mihai G. Netea, Jeffrey D. Cirillo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-10-01
Colecção:	Trials
Assuntos:	COVID-19 Randomized controlled trial BCG vaccination Immune training Pandemic Healthcare workers
Acesso em linha:	https://doi.org/10.1186/s13063-023-07662-w
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