Diversity of oxidative stress and senescence phenotypes induced by chemotherapeutic agents in HUVECs

Abstract Chemotherapy-induced endothelial cell senescence impacts tumor angiogenesis and therapy outcomes. While senescence can suppress tumorigenesis, it may also promote chronic inflammation and vascular toxicity. This study investigates how different chemotherapeutic agents induce senescence in h...

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Autors principals:	Xiaojuan Zhong, Kang Liu, Minhong Zhang, Jiayi Dong, Hai Xiao, Yitao Yang, Siming Chen
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-10-01
Col·lecció:	Scientific Reports
Matèries:	Chemotherapeutic agents Cell senescence HUVECs ROS ATM
Accés en línia:	https://doi.org/10.1038/s41598-025-20652-z
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