Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity

BackgroundInflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are chronic immune-mediated disorders with overlapping clinical and immunological features, yet genome-wide genetic correlation (rg) between them has remained modest.MethodsWe integrated multiple complementary approaches to dis...

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Autori principali:	Yiwen Jia, Yuntian Xia, Siyuan Chen, Guangming Feng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-12-01
Serie:	Frontiers in Immunology
Soggetti:	MiXeR FUMA GWAS shared genetic architecture rheumatoid arthritis (RA) inflammatory bowel disease (IBD)
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1711302/full
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