Hypomorphic Protein Expression of DNA Polymerase Beta in Polβ^{L301R-V303R/L301R-V303R} Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain

DNA polymerase beta (Polβ) is a 39 kDa, single polypeptide enzyme that possesses both gap tailoring and nucleotidyl transferase activity and is the key polymerase involved in base excision repair (BER) and the final steps of active gene demethylation. We demonstrated that residues in the mouse Polβ...

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Autors principals:	Bryce Jacobs, Dan Ivanov, Ivana Barraza, Christopher Faulk, Carmen J. Booth, Raquel Mattos-Canedo, Lucas Tian, Kaitlyn DePietro, Alper Uzun, Wynand P. Roos, Laurie H. Sanders, Robert W. Sobol
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-03-01
Col·lecció:	Biomolecules
Matèries:	DNA polymerase beta demethylation base excision repair Xrcc1
Accés en línia:	https://www.mdpi.com/2218-273X/16/3/412
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