ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines

Summary: ADP-ribosylation (ADPr) signaling plays a crucial role in DNA damage response. Inhibitors against the main enzyme catalyzing ADPr after DNA damage, poly(ADP-ribose) polymerase 1 (PARP1), are used to treat patients with breast cancer harboring BRCA1/2 mutations. However, resistance to PARP i...

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Autori principali:	Holda Awah Anagho, Meeli Mullari, Aurél György Prósz, Sara Charlotte Buch-Larsen, Hayoung Cho, Marie Locard-Paulet, Zoltan Szallasi, Michael Lund Nielsen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-07-01
Serie:	Cell Reports
Soggetti:	CP: Molecular biology CP: Cancer
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124724007629
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