Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma

Abstract Background EGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR or HER2xHER2) and heterodimeric (EGFRxHER2) T cell-engaging bispecific antibodies (T-BsAbs) to direct polyclonal T cells to these antigens on pancreatic tumors...

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Bibliografische gegevens

Hoofdauteurs:	Alan W Long, Hong Xu, Brian H Santich, Hongfen Guo, Sayed Shahabuddin Hoseini, Elisa de Stanchina, Nai-Kong V Cheung
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2024-04-01
Reeks:	Journal of Hematology & Oncology
Onderwerpen:	EGFR HER2 Bispecific antibody Pancreatic ductal adenocarcinoma
Online toegang:	https://doi.org/10.1186/s13045-024-01538-5
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