Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis

VLDLs are crucial for maintaining liver and whole-body lipid homeostasis. Limited knowledge exists regarding the lipidation process of VLDL. Endoplasmic reticulum (ER) luminal lipid droplets (LLDs) have been suggested to provide lipids for VLDL lipidation and maturation. Seipin, an integral membrane...

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Auteurs principaux:	Qianqian Dong, Yidan Ma, Xin Chen, Xiaowei Wang, Ziwei Liu, Chenxi Liang, Liwen Qiu, Jinye Tang, Jin Wu, Yang Liu, Xiaoqin Wu, Yaru Zhou, Mingming Gao, Hongyuan Yang
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2026-03-01
Collection:	Journal of Lipid Research
Sujets:	seipin lipid droplets VLDL liver steatosis fibrosis lipid metabolism
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0022227526000143
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