Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis

Hereditary spherocytosis (HS) is the most common, nonimmune, hereditary, chronic hemolytic anemia after hemoglobinopathies. The genetic defects in membrane function causing HS lead to perturbation of the RBC metabolome, with altered glycolysis. In mice genetically lacking protein 4.2 (4.2–/–; Epb42)...

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Detalhes bibliográficos

Principais autores:	Alessandro Matte, Anand B. Wilson, Federica Gevi, Enrica Federti, Antonio Recchiuti, Giulia Ferri, Anna Maria Brunati, Mario Angelo Pagano, Roberta Russo, Christophe Leboeuf, Anne Janin, Anna Maria Timperio, Achille Iolascon, Elisa Gremese, Lenny Dang, Narla Mohandas, Carlo Brugnara, Lucia De Franceschi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical investigation 2023-10-01
coleção:	JCI Insight
Assuntos:	Hematology Therapeutics
Acesso em linha:	https://doi.org/10.1172/jci.insight.172656
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