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Development of a novel human triculture model of non-alcoholic fatty liver disease and identification of berberine as ameliorating steatosis, oxidative stress and fibrosis

Objectives: Non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) and hepatocarcinoma is a serious and growing problem. However, the development of new therapies is severely hindered by a lack of high-throughput assays for drug testing.Methods: We have...

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Autors principals: Hossein Rafiei, Michelle Yeung, Sara Kowalski, Gerald Krystal, Ingrid Elisia
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2023-10-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2023.1234300/full
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