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A paradoxical relationship between Resveratrol and copper (II) with respect to degradation of DNA and RNA [version 2; referees: 2 approved]

Resveratrol (R), a plant polyphenol, is known to reduce Cu (II) to Cu (I) generating reactive oxygen species that can cleave plasmid DNA. Here we report a surprising observation of a paradoxical relationship between R and Cu whereby plasmid DNA cleaving / degrading activity of R-Cu increased progres...

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Main Authors: Siddharth Subramaniam, Iqbal Vohra, Aishwarya Iyer, Naveen K Nair, Indraneel Mittra
Format: Artigo
Language:Inglês
Published: F1000 Research Ltd 2016-03-01
Series:F1000Research
Subjects:
Cell Signaling & Trafficking Structures
Membranes & Sorting
Structure: RNA
Online Access:http://f1000research.com/articles/4-1145/v2
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