Three Amino Acid Substitutions in the Spike Protein Enable the Coronavirus Porcine Epidemic Diarrhea Virus To Infect Vero Cells

ABSTRACT Porcine epidemic diarrhea virus (PEDV), a continuously evolving pathogen, causes severe diarrhea in piglets, with high mortality rates. To prevent or mitigate the disease, it is common practice to develop live or inactivated PEDV vaccines based on cell-adapted viral variants. Propagating wi...

Descrición completa

Detalles Bibliográficos

Principais autores:	Bingqing Chen, Shijuan Dong, Li Yu, Fusheng Si, Chunhua Li, Chunfang Xie, Ruisong Yu, Zhen Li
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2023-02-01
Series:	Microbiology Spectrum
Assuntos:	PEDV cell adaptation S protein tropism reverse genetics
Acceso en liña:	https://journals.asm.org/doi/10.1128/spectrum.03872-22
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!