Botulinum neurotoxin devoid of receptor binding domain translocates active protease.
Clostridium botulinum neurotoxin (BoNT) causes flaccid paralysis by disabling synaptic exocytosis. Intoxication requires the tri-modular protein to undergo conformational changes in response to pH and redox gradients across endosomes, leading to the formation of a protein-conducting channel. The app...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2008-12-01
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| Serier: | PLoS Pathogens |
| Online adgang: | http://europepmc.org/articles/PMC2596314?pdf=render |
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