Metabolic reprogramming in the post-metastatic tumor microenvironment: multi-omics insights into determinants of immunotherapy response

Metabolic reprogramming has emerged as a central determinant of immune modulation in the post-metastatic tumor immune microenvironment (TIME). Alterations in glycolysis and lactate accumulation, lipid metabolic rewiring, metal-dependent cell death pathways such as ferroptosis and cuproptosis, and th...

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Detalhes bibliográficos

Principais autores:	Mengxi Li, Tingting Wang, Zhenwang Zhang, Yuxi Dongye
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
coleção:	Frontiers in Immunology
Assuntos:	immunotherapy resistance metabolic reprogramming multi-omics integration precision oncology tumor immune microenvironment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1742855/full
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