Interleukin-1 receptor antagonist inhibits metastatic potential by down-regulating CXCL12/CXCR4 signaling axis in colorectal cancer

Abstract Background The aim of this study was to investigate the co-operative role of CXCR4/CXCL12 axis and IL-1Ra in metastatic processes mechanism by interactions between colorectal cancer cells and stromal cells in their microenvironment. Methods Expression of IL-1α, interleukin-1 receptor type I...

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Detalhes bibliográficos

Principais autores:	Jiachi Ma, Wanqing Liang, Yaosheng Qiang, Lei Li, Jun Du, Chengwu Pan, Bangling Chen, Chensong Zhang, Yuzhong Chen, Qingkang Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-12-01
coleção:	Cell Communication and Signaling
Assuntos:	Interleukin-1 receptor antagonist CXCR4-CXCL12 axis Colorectal cancer Metastasis
Acesso em linha:	https://doi.org/10.1186/s12964-021-00804-0
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