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Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis

Abstract Glomerular podocytes play a key role in proteinuric diseases. Accumulating evidence suggests that cGMP signaling has podocyte protective effects. The major source of cGMP generation in podocytes is natriuretic peptides. The natriuretic peptide clearance receptor (NPRC) binds and degrades na...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Liming Wang, Yuping Tang, Anne F. Buckley, Robert F. Spurney
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2021-11-01
Rangatū:Physiological Reports
Ngā marau:
Urunga tuihono:https://doi.org/10.14814/phy2.15095
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