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Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism

Heme oxygenase-1 (HO-1) is an inducible enzyme known for its anti-inflammatory, antioxidant and neuroprotective effects. However, increased expression of HO-1 during aging and age-related neurodegenerative diseases have been associated to neurotoxic ferric iron deposits. Being microglia responsible...

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Principais autores: Cristina Fernández-Mendívil, Enrique Luengo, Paula Trigo-Alonso, Nuria García-Magro, Pilar Negredo, Manuela G. López
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-01-01
coleção:Redox Biology
Assuntos:
Heme oxygenase-1
Microglia
Neuroinflammation
Iron metabolism
Ferroptosis
Aging
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231720309940
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