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Development of Bexarotene Analogs for Treating Cutaneous T-Cell Lymphomas

Bexarotene, a drug approved for treatment of cutaneous T-cell lymphoma (CTCL), is classified as a rexinoid by its ability to act as a retinoid X receptor (RXR) agonist with high specificity. Rexinoids are capable of inducing RXR homodimerization leading to the induction of apoptosis and inhibition o...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ankedo Warda, Lech J. P. Staniszewski, Zhela Sabir, Sarah Livingston, Michael Sausedo, Sabeeha Reshi, Eyal Ron, Michael T. Applegate, Dena Haddad, Madleen Khamisi, Pamela A. Marshall, Carl E. Wagner, Peter W. Jurutka
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2023-11-01
Schriftenreihe:Cells
Schlagworte:
rexinoids
RXR
cutaneous T-cell lymphoma
SAR
cancer
Online-Zugang:https://www.mdpi.com/2073-4409/12/21/2575
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