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Advancing the 3Rs in bone tissue engineering: emerging in vitro, in silico, and refined in vivo strategies

Tissue engineering is an interdisciplinary field integrating materials science, biology, chemistry, and immunology to develop regenerative solutions for complex tissues. Validation of tissue-engineered therapies, however, remains challenging—particularly for bone, whose hierarchical organization gov...

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Furkejuvvon:
Váldodahkkit: Adelaide L. Cagle, Afton K. Limberg, Amritha Anup, Aleyna E. La Croix, Katherine R. Hixon
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2026-05-01
Ráidu:Frontiers in Physiology
Fáttát:
3Rs principles
animal models
bioprinting
bone tissue engineering
in silico modeling
in vitro modeling
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fphys.2026.1811508/full
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