TGF-β/Akt/Smad signaling regulates ionizing radiation-induced epithelial-mesenchymal transition in acquired radioresistant lung cancer cells

Objective: To define the properties of lung cancer cells that resisted conventionally fractionated radiation exposure. Methods: Acquired radioresistant lung cancer cell line A549 was constructed by X-ray irradiation with a clinical conventional fraction dose of 2 ​Gy daily during 30 fractions. Cell...

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Bibliografische Detailangaben

Hauptverfasser:	Yongchun Zhou, Lingli Liao, Nan Su, Hua Huang, Yaoguo Yang, Yan Yang, Gengming Wang, Hongbo Xu, Hao Jiang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2022-09-01
Schriftenreihe:	Radiation Medicine and Protection
Schlagworte:	Ionizing radiation Acquired radioresistance Epithelial-mesenchymal transition Lung cancer cell line A549 Transforming growth factor-beta/Smad/Akt
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2666555722000272
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