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Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses

Abstract NOD2 polymorphisms may affect sensing of the bacterial muramyl dipeptide (MDP) and trigger perturbed inflammatory responses. Genetic screening of a patient with immunodeficiency and enteropathy revealed a rare homozygous missense mutation in the first CARD domain of NOD2 (ENST00000300589; c...

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Principais autores: Maryam Ghalandary, Yue Li, Thomas Fröhlich, Thomas Magg, Yanshan Liu, Meino Rohlfs, Sebastian Hollizeck, Raffaele Conca, Tobias Schwerd, Holm H. Uhlig, Philip Bufler, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Fabian Hauck, Christoph Klein, Daniel Kotlarz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2022-03-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-022-07804-1
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