Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cellsResearch in context

Summary: Background: An intergenic region at chromosome 4q31 is one of the most significant regions associated with COPD susceptibility and lung function in GWAS. In this region, the implicated causal gene HHIP has a unique epithelial expression pattern in adult human lungs, in contrast to dominant...

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Principais autores:	Feng Guo, Li Zhang, Yuzhen Yu, Lu Gong, Shiyue Tao, Rhiannon B. Werder, Shreya Mishra, Yihan Zhou, Wardatul Jannat Anamika, Taotao Lao, Hiroyuki Inuzuka, Yihan Zhang, Betty Pham, Tao Liu, Tiffany S. Tufenkjian, Bradley W. Richmond, Wenyi Wei, Hongmei Mou, Andrew A. Wilson, Ming Hu, Wei Chen, Xiaobo Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-03-01
Series:	EBioMedicine
Assuntos:	Chronic obstructive pulmonary disease Distal enhancer Hi-C Epithelial-mesenchymal transition TGFβ Epigenetics
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2352396424000616
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