Prolyl-isomerase Pin1 drives platinum resistance by regulating Notch3 stability and function in ovarian cancer

Abstract Background Resistance to platinum-based drugs represents a major obstacle for the management of high-grade serous ovarian cancer (HGSOC) patients. Indeed, the selective pressure of platinum-based (PT) chemotherapy often leads to the outgrowth of platinum-resistant subclones. In this scenari...

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Bibliografiske detaljer

Principais autores:	Maria Valeria Giuli, Angelica Mancusi, Bianca Natiello, Samuele Di Cristofano, Rebecca Reali, Maria Gemma Pignataro, Daniel D’Andrea, Laura Di Magno, Carmine Nicoletti, Alessandra Giorgi, Alberto Macone, Serena Camerini, Marialuisa Casella, Giovanna Peruzzi, Sabrina Zema, Gianluca Canettieri, Federica Tomao, Innocenza Palaia, Angelina Pernazza, Alessandra Rustighi, Rocco Palermo, Domenico Raimondo, Alessandra Monti, Nunzianna Doti, Giulia d’Amati, Giannino Del Sal, Isabella Screpanti, Claudio Talora, Diana Bellavia, Saula Checquolo
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2026-02-01
Serier:	Journal of Experimental & Clinical Cancer Research
Fag:	HGSOC Pin1 targeting Notch3 Platinum drug resistance
Online adgang:	https://doi.org/10.1186/s13046-026-03658-x
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