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Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol induced hepatotoxicity after paracetamol overdose in rats

The aim of this study was to evaluate small doses of known cytochrome P450 enzyme inhibitors, grapefruit juice (GFJ) and one of its components, bergamottin (BGT), for the prevention of paracetamol (PAR)-induced hepatotoxicity after overdose in rats. Six groups of 15 Sprague Dawley (SD) rats each wer...

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Principais autores: Refuoe Baleni, Zanelle Bekker, Andrew Walubo, Jan B. Du Plessis
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-01-01
Serier:Toxicology Reports
Fag:
Paracetamol
Overdose
Grapefruit juice
Hepatotoxicity
Prevention
Bergamottin
Online adgang:http://www.sciencedirect.com/science/article/pii/S2214750015000566
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