Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis

Abstract Background One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to obtain rationale for designing anti-inflammatory clinical trials targeti...

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Detalhes bibliográficos

Principais autores:	Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Katherine Sward, J. Michael Dean, H. J. Park, Joseph A. Carcillo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-09-01
coleção:	Critical Care
Assuntos:	Severe sepsis Multiple organ failure Immunoparalysis Thrombocytopenia-associated multiple organ failure Macrophage activation syndrome Hyperferritinemic sepsis
Acesso em linha:	https://doi.org/10.1186/s13054-023-04628-x
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