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A New Class of Benzo[<em>b</em>]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies

In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated. Benzothiophenes <b>4a</b>–<b>4i</b> and benzothiophene-chalcone hybrids <b>5a<...

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Autori principali: Giovanna Lucia Delogu, Michela Begala, Maria João Matos, Davide Crucitti, Valeria Sogos, Benedetta Era, Antonella Fais
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-08-01
Serie:Molecules
Soggetti:
benzothiophenes
heterocycles
cholinesterase inhibitors
Accesso online:https://www.mdpi.com/1420-3049/29/16/3748
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