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TPGS-b-PBAE Copolymer-Based Polyplex Nanoparticles for Gene Delivery and Transfection In Vivo and In Vitro

Poly (β-amino ester) (PBAE) is an exceptional non-viral vector that is widely used in gene delivery, owing to its exceptional biocompatibility, easy synthesis, and cost-effectiveness. However, it carries a high surface positive charge that may cause cytotoxicity. Therefore, hydrophilic d-α-tocophero...

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Principais autores: Jiahui Ding, Handan Zhang, Tianli Dai, Xueqin Gao, Zhongyuan Yin, Qiong Wang, Mengqi Long, Songwei Tan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-01-01
Serier:Pharmaceutics
Fag:
poly (β-amino ester)
gene transfection
D-α-tocopherol polyethylene glycol succinate
copolymer
CRISPR/cas9 gene editing
gene therapy
Online adgang:https://www.mdpi.com/1999-4923/16/2/213
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