Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts.
Chondrocytes proliferate and mature into hypertrophic chondrocytes. Vascular invasion into the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal hypertrophic chondrocytes die by apoptosis or transdifferentiate into osteoblasts. Runx2 is essential for osteoblast differenti...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science (PLoS)
2020-11-01
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| Schriftenreihe: | PLoS Genetics |
| Online-Zugang: | https://doi.org/10.1371/journal.pgen.1009169 |
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