Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead

The constitutive and dysregulated expression of the transcription factor MYCN has a central role in the pathogenesis of the paediatric brain tumour medulloblastoma, with an increased expression of this oncogene correlating with a worse prognosis. Consequently, the genomic and functional alterations...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Sumana Shrestha, Alaide Morcavallo, Chiara Gorrini, Louis Chesler
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2021-06-01
Σειρά:	Frontiers in Oncology
Θέματα:	MYCN medulloblastoma targeted therapy metabolism immunotherapy PROTACs
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fonc.2021.694320/full
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